Almost all healthy people carry stains from mutant cells


A recent study found that large groups of cells in healthy tissue had mutations, including those related to cancer.

About 95% of healthy people have mutant cell spots on at least one of the 29 tissues examined, including kidneys, muscles and liver tissue, the researchers said in a June 7 report. Most of the mutations found in 488 individuals in this study are harmless, but some are associated with various cancers.

About 40% of tissues have at least most mutant cells and about 5% of the samples tested have five or more mutant plasters, said Keren Jiajak from MIT Institute and Harvard.

The skin, esophagus and lungs have more than these mutated sites than other tissues, the researchers noted. These three types of tissue are exposed to more ultraviolet light, pollution, smoke, or other environmental factors that can cause mutations than internal organs that are not directly exposed to these external factors. In people of European descent, sun-exposed skin has more mutations than closed skin. African Americans do not have the same increase in mutations of skin exposed to sunlight.

Age also affects the number of mutations, with mutations occurring more often after the age of 45 in dividing tissue to form new cells. Networks that do not grow actively do not tend to form age-related mutations.

It is not yet possible to know how thin tissue becomes cancer, but this research is the first step in answering that question, a cancer researcher at Johns Hopkins Medical School, Christian Thomas. Science.

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