Changes in the brain can explain why exercise reduces autism in mice


Exercise seems to change the brain in a way that can reduce some features of autism in mice.
In ASD mice, researchers at the University of Tokyo in Japan have found that exercise stimulates the elimination of unnecessary relationships in the brain and reduces behaviors such as autism.

In an article by Cell Reports about their work, they explained how they have shown that “voluntary wheel movements increase anomalies in terms of portability, repetition, and anxiety” in ASD rats.

The results reinforce the notion that it is possible to overcome some of the characteristics of ASD behavior.

Senior investigator Ryuta Koyama, a professor at the University of Tokyo College of Pharmacy, said he did not force mice to exercise. The voluntary nature of physical activity is an important feature of this study.

In addition, the researchers did not study various types of exercise and did not advise people to start exercise as an ASD treatment.

“If children are interested,” Koyama said, “they should be encouraged to do the desired exercise, but this study does not show how various activities can affect the brains of ASD children.”

ASD, connectivity and brain movement

ASD includes various subtypes that share several common features in various degrees. These features include repetitive behavior and difficulties in verbal and nonverbal communication and social interaction.

No two individuals in the autism spectrum share the same combination or level of symptoms. Each of them will have a number of challenges and strengths. Some people with ASD can live independently, while others need a lot of help in their daily lives.

According to the Centers for Disease Control and Prevention (CDC), about 1 in 59 children in the United States suffer from ASD, with boys suffering from ASD four times more often than girls.

Excessive connections between neurons or neurons in the brain are characteristic of ASD.

The brain naturally removes unnecessary connections between neurons during childhood. Children with ASD, however, have a surplus.

Many studies have shown that physical activity can cause significant changes in the brain of healthy people and can even slow down some of the brain degeneration that accompanies aging.

Scientists who conducted a small study in children with ASD also found that exercise reduces repetitive behavior and the difficulties of social interaction.

Recently, researchers have found that the brain ring relationship lasts longer in people with ASD than in people without interference. It also appears that the severity of symptoms increases with the duration of the relationship.

Train and remove weak limbs

A new study from Japan shows that exercises that trigger the elimination of unnecessary connections can result in “fine-tuning” the brain in ASD.

Assuming results were found in ASD mice, Koyama suggested: “Exercise can increase the contrast between active and inactive neuronal connections, making it easier to remove weaker ones.”

Rats raised as ASD models show features that are very durable. For example, they don’t often interact with mice they have never met before, and they are involved in repetitive slips. They also show signs of anxiety, such as slowing down food consumption in new environments.

For the new study, the team placed 4 weeks of ASD rats in cells. They then monitor them to adult mice at the age of 8 weeks.

Coyama said that some mice “practice very intensively” while others “just train a little”.

The team found that the behavior of mice treated with ASD after only 30 days was similar to healthy mice without ASD.

The researchers then examined the brains of mice with ASA. They pay special attention to certain structures in the hippocampus, an important area for memory, which creates new nerve cells in the adult brain.

They have found evidence that microglia, immune cells that lift dead cells and other debris to the brain have eliminated fewer active connections between nerve cells, leaving the drug intact.

To show that microglia was cut off, the team then tested the effect of preventing microglial activity in immature mice without ASA. Only after 5 days without microglial activity, the density of brain compounds differed from those in mice with intact microglial activity.

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