Infertility is associated with a dangerous heart condition during pregnancy


Women treated with fertility may be at higher risk for dangerous pregnancies known as peripartric cardiomyopathy.

However, it is unlikely that an increased risk is related to the treatment itself. Instead, the researchers claim that the factors that contribute to infertility can also make this type of heart failure more common.

In a new study presented at the Conference on Heart Failure Saturday (May 25) in Athens, Greece, German researchers reported that women who received infertility treatment with five times the risk of peripartumalin cardiomyopathy than those on therapy had fertility treatments. become pregnant. However, according to his research, infertility does not affect the recovery of peripartumnata cardiomyopathy patients, which are still published in scientific journals reviewed by peers.

Infertility and cardiomyopathy
Peirpartum cardiomyopathy is a type of heart failure that occurs during pregnancy or within a few months after birth. This condition affects about 1 in 1,000 to 4,000 pregnancies that cause live births. This emerged from an article from 2016 in the journal Circulation. Most women recover, but peripheral cardiomyopathy can be fatal. A 2015 study published in the journal Obstetrics & Gynecology found that conditions between 2002 and 2005 were responsible for 23% of maternal deaths in California.

“We still have to argue about what causes peripheral cardiomyopathy,” Dr. Ileana Piñata, a cardiologist at Albert Einstein Medical College, who was not involved in this study. There are several risk factors, Pinya said in life sciences, including African-Americans and more than pregnancy.

In the new work, a medical student Manuel Liszt and colleagues from Hannover Medical School in Germany collected data from 108 patients with peripartumalna cardiomyopathy in their clinic. The researchers studied the patients’ blood for molecular markers of infertility and then compared these patients with 24 pregnant women without cardiomyopathy.

Thirty-two percent of patients with peripartum cardiomyopathy report problems with conception. Thirteen percent need the idea of ​​help, with most help coming in the form of in vitro fertilization followed by hormone treatment.

In the German population, 20% of pregnant women suffer from infertility problems and 2.6% of babies are conceived with assistance.

The researchers also observed changes in plasma infertility markers in patients with infertility in cardiomyopathy.

Risk factors
Part of the clear connection between peripartumnata cardiomyopathy and possible infertility is that women undergoing infertility treatment are older than those who are not aware, study co-author Denise Hilfiker-Dean of Small Research in Imagine Cardiology Molecular Cardiology at Hannover Medical College. said a statement. Infertility treatment also causes more twin or multiple pregnancies, he said, which carries an increased risk of peripartumalna cardiomyopathy, also known as PPCM.

“We also believe that there may be genetic changes that make women more likely to experience subfertility and PCM, but this analysis continues,” according to the List statement. “So far, there is no clear evidence that hormone treatment which is usually part of fertility therapy increases the risk of PPC.”

The results showed that women who undergo fertility treatment should be very familiar with the symptoms of PPCM. These symptoms can mimic the symptoms of pregnancy, so they are sometimes ignored, Pinya said. These include swelling of the legs and legs, which does not disappear when the extremities rise, lack of air and fatigue. The treating doctor will look for lung fluid according to the American Heart Association.

About one third of patients with peripartum cardiomyopathy fully recover after treatment, said Pinya. In about one third of cases, this disease is fatal. The remaining patients survived but were never able to fully restore heart function. In this case, the doctor recommends not to get pregnant again, said Pinya, because recurrence of the disease can cause more damage to the heart.

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