Iron “starving” sponges can cure drug-resistant infections


Recent studies in mice divert drugs for blood disorders that are resistant to antibiotics, iron sponges that starve, thereby halving the survival of yeast.

In the United States, at least 2 million people develop antibiotic-resistant infections every year and 23,000 die from it.

The crisis of drug resistance is so terrible that some researchers can warn that it immediately warns “the pre-antibiotic era, in the light of more infections can be fatal.”

The Centers for Disease Control and Control (CDC) categorizes this threat as “urgent,” “serious,” or “more” antibiotic resistance.

The CDC believes that fluconazole-resistant Candida, which causes 3,400 infections and 220 deaths each year, is a “serious” threat.

Why is it important to manage Candida?

Candida albicans is a fungus that can cause stomastite associated with the oral cavity and dentures among other infections during healing.
C. albicans also causes the fourth cause of blood flow infection ratings, hospital admission, Dr. Mira Edgertan, co-founder of the new study, described an innovative way to prevent infection with Candida.

The scientist, who is also a researcher in the Department of Oral Biology at the University of Buffalo School of Dentistry in New York, added that currently there are only three main classes of antifungal and no new antifungal classes. for decades.

“In the absence of new drug candidates, directing drugs should be a promising strategy for existing drugs to treat disease,” the professor added. Edzhartan.

The team published its findings in the journal Antimicrobial Agents and Chemotherapy.

Iron gradient falls in C. albicans

The authors explain that C. albicans is the most common fungus in the oral microbiome and depends on saliva to get the essential nutrients needed to survive.
In particular, C. albicans requires iron to produce energy and repair its DNA. Iron is also the second most common metal in saliva.
In the new study, Prof. Eugarton and his team gave deferasirox, a drug for mice with C. albicans. Medication reduces iron levels. In this way, it burns C. albicans from the basic nutrients needed to maintain infection.

Scientists compared the effects on mice that received care and those who did not.

They found that in the group with deferasirox C. albicans only had 12% survival while fungi did not have 25% survival in mice, deferasirox did not receive.

This reduced survival rate occurs because the neutrophilic phagosome of C. albicans becomes more susceptible to oxidative stress and also decreases twice.

Furthermore, in mice that received deferasirox, C. albicans, changes in gene expression were involved in iron metabolism, adhesion and response to host immunity.

Sumant Puri, Ph.D. – Researchers are also leading the research and Assistant Professor in the School of Dentistry at Temple University Kornberg, Philadelphia, Pennsylvania, he said the study was the first to find that iron starvation alters the expression of the C. albicans gene during live infection.

He added that the adult mouse model found that treatment with deferasirox did not cause iron deficiency, indicating that the drug could be used as a preventive treatment.

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